Hippocampal Neurogenesis (HPN)

Hippocampal neurogenesis is the process of generating new neurons in the hippocampus, a brain region crucial for memory and spatial navigation. It occurs throughout life, primarily in the dentate gyrus, and involves the proliferation of neural stem cells, their differentiation into neuroblasts and immature neurons, and the maturation and integration of these new neurons into existing hippocampal circuits. This process is regulated by intrinsic factors, extrinsic signals, and environmental stimuli and plays a key role in learning, memory, and emotional regulation. Alterations in hippocampal neurogenesis are implicated in cognitive decline and mood disorders.

Other names

Adult Hippocampal NeurogenesisAHNNeurogenesis in the Dentate Gyrus

Not applicable, as it is a biological process rather than a single target. Interventions aim to modulate the rate or efficiency of the neurogenic process.