Hippocampal somatostatin-positive GABAergic interneuron population (Hippocampal SST+ interneurons)

The hippocampal somatostatin-positive (SST+) GABAergic interneuron population is a specialized group of inhibitory neurons crucial for regulating hippocampal circuitry and memory formation (Source: Pelkey et al., 2017, Physiological Reviews). These neurons, which include subtypes like Oriens-lacunosum moleculare (O-LM) cells, primarily provide inhibition to the distal dendrites of pyramidal cells, thereby gating excitatory inputs and controlling synaptic plasticity (Source: Müller and Remy, 2018, Frontiers in Cellular Neuroscience). They play a fundamental role in generating network oscillations, particularly theta rhythms, which are essential for spatial navigation and memory encoding (Source: Klausberger and Somogyi, 2008, Science). In various neurological and psychiatric disorders, such as Alzheimer's disease and epilepsy, there is a notable loss or dysfunction of these SST+ interneurons, leading to network hyperexcitability and cognitive deficits (Source: Stefanelli et al., 2016, Neuron). While not a single molecular target, this cell population is a focus of therapeutic strategies aimed at restoring inhibitory balance through GABAergic modulation or somatostatin receptor agonism (Source: Liguz-Lecznar et al., 2016, Neuroscience & Biobehavioral Reviews).

Other names

SST+ interneuronsHippocampal somatostatin-expressing neuronsO-LM cells (Oriens-lacunosum moleculare cells)HIPP cells (Hilar interneurons with perforant path-associated axon terminals)Somatostatin-positive GABAergic inhibitory network

Modulation of inhibitory neurotransmission via GABA release and somatostatin signaling to regulate pyramidal cell excitability and network synchrony.