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Target intelligence / Profile preview
Histamine N-methyltransferase (HNMT)
- Target
- HNMT
- Molecular classification
- Enzyme, Methyltransferase, Class I-like SAM-binding methyltransferase superfamily
01
Overview
Histamine N-methyltransferase (HNMT) is an enzyme that catalyzes the methylation of histamine, inactivating it. It transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine, producing Nτ-methylhistamine. This is a major histamine inactivation pathway, particularly in the central nervous system. HNMT plays a critical role in modulating allergic reactions, neurotransmission, gastric acid secretion, and other histamine-related processes. Alterations in HNMT function can affect susceptibility to allergic diseases.
- Other names
- Histamine N-methyltransferase isoform 1HMTHNMT-S1HNMT-S2MRT51
02
Mechanism of action
Inhibition of histamine N-methylation
03
Biological functions
Histamine degradationRegulation of histamine-mediated responsesNeurotransmission modulationAllergic reaction modulationGastric acid secretion modulation
04
Disease associations
Allergic diseasesAsthmaMastocytosisAnaphylaxis
05
Safety considerations
Potential for altered histamine metabolism affecting allergic reactions or drug responsesSubstrate inhibition at high concentrations
06
Interacting drugs
Tacrine
1 more in the full profile.
07
Biomarkers
Urinary Nτ-methylhistamine (Nτ-MH)
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