Histamine receptor 4 (H4R)

The Histamine H4 receptor is a member of the G protein-coupled receptor family primarily expressed on various immune cells such as mast cells, eosinophils, T cells, and in bone marrow[1][2]. It plays a key role in mediating chemotaxis and activation of these immune cells during inflammatory and allergic responses. The stabilization or inhibition of histamine signaling through this receptor has been proposed as a therapeutic strategy for treating conditions involving chronic inflammation or allergy. Research into selective antagonists for the H4 receptor is ongoing due to its involvement in modulating immune cell migration and cytokine production[1][3]. Note on target name correctness: The provided target name "Histamine receptor-expressing immune cells stabilization" does not refer to a specific molecule but rather describes an effect or process. The correct molecular target relevant here is the Histamine H4 receptor, which mediates many immunomodulatory effects attributed to histamine signaling in immune cell populations[1][2][3]. Thus, "Histamine receptor-expressing immune cells stabilization" should be mapped specifically to "Histamine H4 receptor," with an annotation that the original entry was imprecise or overly broad.

Other names

Histamine H4 receptorHRH4H4 histamine receptor

Antagonists block histamine binding to the H4 receptor on immune cells, reducing chemotaxis and inflammatory cytokine release[1][3].