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Target intelligence / Profile preview
Histamine Receptor H2 Subtype
- Molecular classification
- G protein-coupled receptor, GPCR, Family 1/rhodopsin-like GPCRs
01
Overview
The histamine receptor H2 is a member of the rhodopsin-like family of G protein-coupled receptors (GPCRs). It is an integral membrane protein that plays a central role in mediating the physiological effects of histamine, particularly in stimulating gastric acid secretion. It couples primarily to the Gs alpha subunit, leading to activation of adenylate cyclase and increased cyclic AMP (cAMP) production.
- Other names
- H2 receptorHRH2
02
Mechanism of action
H2 receptor antagonists competitively block the binding of histamine to H2 receptors on parietal cells, reducing gastric acid secretion.
03
Biological functions
Stimulation of gastric acid secretionRegulation of gastrointestinal motilityRegulation of intestinal secretionModulation of cell growthModulation of cell differentiationVasodilationNeurotransmission
04
Disease associations
Gastroesophageal reflux disease (GERD)Peptic ulcersZollinger-Ellison syndrome
05
Interacting drugs
Famotidine
2 more in the full profile.
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