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Target intelligence / Profile preview
Histamine Receptor H4 (H4)
- Target
- H4
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Class A GPCR
01
Overview
The Histamine Receptor H4 (H4) is an immunoregulatory G protein-coupled receptor (GPCR) primarily expressed on hematopoietic and immune system cells. It plays a crucial role in inflammation and allergy pathways by controlling immune cell migration, recruitment, and activation. This makes it a promising therapeutic target for anti-inflammatory therapies targeting allergic conditions, asthma, chronic itch, autoimmune diseases, and other inflammatory disorders.
- Other names
- HRH4
02
Mechanism of action
Agonism or antagonism of H4 receptor to modulate immune cell migration and activation.
03
Biological functions
Immune regulationChemotaxisCell migrationInflammatory responseSignal transductionActin polymerizationCytokine productionDendritic cell activationT cell differentiation
04
Disease associations
Allergic conditionsAsthmaChronic itch/pruritusAutoimmune diseasesInflammatory disorders
05
Interacting drugs
JNJ 7777120
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