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Target intelligence / Profile preview
Histamine Release (N/A)
- Target
- N/A
- Molecular classification
- Cellular process, Secretion
01
Overview
Histamine release refers to the process by which the biogenic amine histamine is liberated from storage sites within cells, primarily mast cells and basophils, into surrounding tissues or circulation. This event is a central component of immune responses, particularly in allergic reactions and inflammation. Excessive or inappropriate histamine release underlies many allergic conditions and may contribute to autoimmune diseases and persistent inflammatory states.
- Other names
- Histamine secretionDegranulation (mast cells/basophils)Histamine liberation
02
Mechanism of action
N/A (process itself, not a drug target). Drugs can inhibit specific receptors (H1, H2, etc.) or stabilize mast cells to prevent degranulation.
03
Biological functions
Immune responseInflammationVasodilationIncreased vascular permeabilityGastric acid secretionNeurotransmissionImmune cell migration
04
Disease associations
Allergic reactionsAnaphylaxisAsthmaUrticariaRhinitisConjunctivitisAutoimmune diseasesInflammatory disorders
05
Safety considerations
Systemic vasodilation causing hypotensionBronchoconstriction leading to respiratory distressIncreased gastric acid secretionPotential for anaphylaxis
06
Interacting drugs
Morphine
3 more in the full profile.
07
Biomarkers
Serum histamine levelsMast cell tryptaseUrinary histamine metabolites
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