Histamine release from basophils

Histamine release from basophils is a critical event in the immune response, particularly in allergic and inflammatory processes. Basophils, when triggered by stimuli such as allergen-bound IgE cross-linking their surface FcεRI receptors, rapidly degranulate and secrete histamine and other mediators. This leads to vasodilation, increased vascular permeability, and recruitment of other immune cells, which underlies symptoms of allergy, asthma, and anaphylaxis. The process is regulated by various activating and inhibitory receptors, and certain drugs aim to either block histamine's action or suppress its release to treat allergic conditions[1][2][5][7].

Other names

basophil degranulationbasophil histamine secretion

Receptor antagonism (antihistamines block histamine receptors downstream of release); Membrane stabilization (e.g., cromolyn inhibits degranulation); Inhibition of IgE binding/crosslinking (e.g., omalizumab prevents basophil activation); Inhibition of signaling molecules involved in degranulation (e.g., glucocorticoids inhibit signaling cascades)