Target intelligence / Profile preview

Histamine Release Inhibitor

Molecular classification: Other

Overview

A histamine release inhibitor is any molecule or agent that prevents or reduces the release of histamine from cells, particularly mast cells and basophils. Histamine is a key mediator in allergic reactions, inflammation, and immune responses. By inhibiting its release, these agents can modulate symptoms associated with allergies, asthma, pruritus (itch), and other inflammatory conditions.

Mechanism of action

Inhibition of mast cell degranulation; Modulation of intracellular calcium; Endogenous feedback mechanisms

Biological functions

Inhibition of histamine releaseModulation of mast cell degranulationRegulation of inflammation

Disease associations

Allergic diseasesAsthmaInflammationUrticariaAnaphylaxis

Interacting drugs

Indomethacin

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