Target intelligence / Profile preview

Histamine succinyl glycine (HSG)

Target: HSG
Molecular classification: Hapten, Synthetic molecule

Overview

Histamine succinyl glycine (HSG) is a synthetic hapten used in molecular imaging and pretargeted radioimmunotherapy. It functions as a target for engineered antibodies or antibody fragments, enabling targeted delivery of imaging agents or therapeutics to specific sites, such as tumors. It does not act on endogenous receptors but relies on the specificity of anti-HSG antibodies.

Other names: histaminyl-succinyl-glycinedi-HSG

Mechanism of action

Acts as an artificial target for engineered antibodies or scFv fragments. Facilitates targeted delivery of imaging agents or therapeutics by binding to pre-localized antibodies at the target site (e.g., tumor).

Biological functions

Molecular imagingPretargeted radioimmunotherapyTarget for engineered antibodies

Disease associations

Cancer (imaging and therapy targeting)

Safety considerations

Immunogenicity of anti-HSG antibodiesOff-target binding of radiolabeled HSG hapten

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