Histamine-succinyl-glycine motif

The term "Histamine-succinyl-glycine motif" does not refer to any established therapeutic target such as a receptor, enzyme, transporter, or other well-characterized protein. Instead, it appears to describe either: 1. A chemical moiety—specifically the histamine molecule covalently linked via succinylation and glycine—to form an artificial hapten structure. 2. A synthetic recognition element used in laboratory assays (e.g., phage display selection of antibodies against small molecules), where the histamine-succinyl group is essential for antibody recognition but is not itself a biological macromolecule or druggable entity. There is no evidence that "histamine-succinyl-glycine motif" represents any naturally occurring protein domain, receptor family member (such as G protein-coupled receptors like the histamine H1–H4 receptors), nor is it listed among standard molecular targets in pharmacology databases. The phrase may arise from technical literature describing assay reagents rather than bona fide drug targets. If you are seeking information on actual histamine receptors (such as Histamine H1 receptor), those are well-established GPCRs involved in allergy and inflammation responses and have many approved drugs targeting them. However, "histamine-succinyl-glycine motif" itself should be considered an incorrect entry if intended to represent such targets. The histamine-succinyl moiety has been described only as an essential recognition element for certain antibodies generated by phage display against haptens—not as a functional biological molecule or therapeutic target. There is no evidence supporting its role beyond being part of synthetic constructs used in research settings. In summary: This entry does not correspond to any recognized canonical molecular target. It should be flagged for correction if included among lists of druggable proteins/receptors.

Not applicable In the context of immunoassays, may serve as an epitope for antibody binding