Histidine protein methyltransferase 1 homolog (METTL18)

Histidine protein methyltransferase 1 homolog (METTL18) is a protein methyltransferase that specifically methylates histidine 245 on the ribosomal protein RPL3[1]. This τ-N-methylation modification of RPL3 slows translation elongation specifically at tyrosine codons, ensuring nascent protein folding and maintenance of proteome quality, particularly by protecting cells against aggregation of tyrosine-rich proteins. METTL18 functions primarily as a translational modulator and quality control factor, and altered function or expression of this enzyme may play a role in diseases such as cancer by disturbing protein homeostasis[1][2].

Other names

Histidine protein methyltransferase 1 homologMETTL18Arsenic-transactivated protein 2ASTP2C1orf156AsTP2HPM1Methyltransferase-like protein 18histidine protein methyltransferase 1MGC9084

Catalyzes τ-N-methylation of histidine 245 on RPL3, modifying ribosomal function[1]