Histidine rich carboxyl terminus 1 (HRCT1)

Histidine rich carboxyl terminus 1 (HRCT1) is a protein-coding human gene believed to be involved in maintaining epithelial integrity, possibly as a membrane or structural protein, especially in the alveolar epithelium. It is highly expressed in several tissues and displays altered transcript levels in certain malignancy states, including colorectal and liver cancer stem-like cells. There is insufficient evidence that HRCT1 functions as a receptor, enzyme, or any classical drug target, nor is it associated with recognized drug mechanisms or safety concerns. Instead, HRCT1’s role appears limited to basic cell and tissue structure. There is confusion involving histidine-rich proteins; for example, "histidine-rich calcium binding protein" is a completely different and well-characterized protein mostly in muscle tissue, and "histidine-rich glycoprotein" (HRG) is yet another distinct protein. No established drug targeting or molecular pathway is described for HRCT1, although its expression is altered in various cancers according to transcriptomic studies. In summary: HRCT1 is not a recognized therapeutic target, receptor, enzyme, transporter, or member of any classical druggable protein families. It is primarily classified as a structural protein, with possible roles in tissue integrity and cancer-associated gene expression, but its molecular function and therapeutic significance remain speculative.

Other names

Histidine-rich carboxyl terminus protein 1HRCT1UNQ338/PRO537LGLL338PRO537UNQ338