Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Histidine–tRNA ligase (HisRS)
- Target
- HisRS
- Molecular classification
- Enzyme, Aminoacyl-tRNA synthetase
01
Overview
Histidine–tRNA ligase, also known as histidyl-tRNA synthetase (HisRS or HARS), is an enzyme that catalyzes the attachment of L-histidine to tRNA^His, essential for protein biosynthesis. It functions as a homodimer and is a target of autoantibodies in autoimmune diseases.
- Other names
- histidyl-tRNA synthetaseJo-1histidyl-transfer ribonucleate synthetasehistidine translaseHARS
02
Biological functions
Aminoacylation of tRNA(His)Protein synthesisHistidine metabolismAminoacyl-tRNA biosynthesis
03
Disease associations
Autoimmune diseasePolymyositisDermatomyositisRheumatoid arthritisMyositis
Beyond the preview
Go deeper on Histidine–tRNA ligase (HisRS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Histidine–tRNA ligase (HisRS).