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Histone

Molecular classification: Protein, DNA packaging, Structural protein

Overview

Histones are small basic nuclear proteins essential for packaging eukaryotic genomic DNA into organized structures called nucleosomes; they regulate access to genetic information via chemical modification ("epigenetic regulation"), participate actively in chromosome maintenance/division/repair processes, exist as several types/variants tailored for specific functions within chromatin architecture—and their misregulation underlies many human diseases including cancer.

Biological functions

DNA PackagingStructural SupportGene RegulationChromatin RemodelingChromosome segregationGenome stability

Disease associations

Cancer

Safety considerations

Misregulation or mutation in genes encoding histones/chaperoning machinery is linked with diseases such as cancer due to altered chromatin landscapes affecting gene activity

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