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Target intelligence / Profile preview
Histone Deacetylase 1 (HDAC1)
- Target
- HDAC1
- Molecular classification
- Enzyme, Histone Deacetylase, Class I HDAC
01
Overview
Histone deacetylase 1 (HDAC1) is a nuclear enzyme essential for epigenetic regulation through removal of acetyl groups from lysine residues on core histones and other proteins. As part of multi-protein repressive complexes such as Sin3A or NuRD—and regulated by cofactors including zinc ions—its activity shapes chromatin architecture to control gene expression programs vital for development but also implicated in cancer when dysregulated.
02
Mechanism of action
Inhibition of histone deacetylase activity, leading to increased acetylation of histones and altered gene expression.
03
Biological functions
Chromatin remodelingGene silencingCell cycle regulationRegulation of transcriptionCell proliferationApoptosis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad substrate specificity of HDAC inhibitorsToxicity associated with altered gene expression profiles
06
Interacting drugs
Class I/IIa/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x/y/z HDAC inhibitors
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