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Histone Deacetylase 10 (HDAC10)
- Target
- HDAC10
- Molecular classification
- Enzyme, Histone modification, Hydrolase, Class IIb histone deacetylase, Polyamide deacetylase
01
Overview
Histone Deacetylase 10 (HDAC10) is a class IIb histone deacetylase enzyme involved in regulating chromatin structure, gene expression, and cellular processes like autophagy and DNA repair. It exhibits robust polyamine deacetylase activity, particularly towards N8-acetylspermidine. HDAC10 is implicated in cancer due to its roles in cell survival and proliferation pathways, making it a potential therapeutic target for selective inhibitor development.
02
Mechanism of action
Inhibition of histone and polyamine deacetylation
03
Biological functions
Regulation of chromatin structureTranscriptional repressionAutophagyRegulation of cyclin A2 expressionDNA mismatch repairPolyamine metabolismCell proliferationCell survival
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects with non-selective inhibitorsDysregulation of polyamine metabolism
06
Interacting drugs
Trichostatin A
3 more in the full profile.
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