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Target intelligence / Profile preview
Histone Deacetylase 11 (HDAC11)
- Target
- HDAC11
- Molecular classification
- Enzyme, Histone Deacetylase, Class IV Histone Deacetylase
01
Overview
Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family, classified as the only member of Class IV HDACs. It deacetylates lysine residues on histones and exhibits robust defattyacylase activity. It plays roles in immunomodulation, genomic stability, cell cycle progression, and nervous system development. Aberrant expression or function is linked to metabolic disorders, cancer, and other conditions. Several selective inhibitors have been developed targeting its unique enzymatic activities.
02
Mechanism of action
Inhibition of histone deacetylase activity, inhibition of defattyacylase activity
03
Biological functions
ImmunomodulationGenomic StabilityCell Cycle ProgressionNervous System DevelopmentLysine deacetylationDefattyacylation
04
Disease associations
Metabolic DisordersObesityDiabetesMetabolic SyndromeCancerOxidant Stress InjuryNeurological DysfunctionSubstance Abuse
05
Interacting drugs
SIS17
5 more in the full profile.
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