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Target intelligence / Profile preview
Histone deacetylase 2 (HDAC2)
- Target
- HDAC2
- Molecular classification
- Enzyme, Histone modification, Histone deacetylase, Zinc-dependent hydrolase
01
Overview
Histone deacetylase 2 (HDAC2) is a zinc-dependent enzyme that plays a central role in the regulation of gene expression by catalyzing the removal of acetyl groups from lysine residues on histone proteins, leading to chromatin condensation and transcriptional repression. It belongs to class I histone deacetylases and is considered a general oncoprotein due to its role in promoting tumorigenesis. HDAC2 often functions as part of large multiprotein complexes and can also act on non-histone proteins to regulate their function.
- Other names
- HDAC2hda1RPD3
02
Mechanism of action
Inhibition of histone deacetylase activity, leading to increased acetylation of histones and altered gene expression.
03
Biological functions
Transcriptional regulationCell cycle progressionDevelopmental eventsChromatin compactionGene repression
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Dysregulation of synaptic plasticityPotential for off-target effects due to broad expression
06
Interacting drugs
Vorinostat (SAHA)
1 more in the full profile.
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