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Target intelligence / Profile preview
Histone Deacetylase 3 (HDAC3)
- Target
- HDAC3
- Molecular classification
- Enzyme, Histone modification, Histone Deacetylase, Class I Histone Deacetylase
01
Overview
Histone deacetylase 3 (HDAC3) is a Class I histone deacetylase enzyme that plays a central role in chromatin remodeling, transcriptional regulation, and various cellular processes including cell growth, differentiation, and apoptosis. It catalyzes the removal of acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. Aberrant HDAC3 activity has been linked to cancer development/progression, making it a therapeutic target.
02
Mechanism of action
Pharmacological inhibition/downregulation of HDAC3 activity
03
Biological functions
Transcriptional regulationChromatin remodelingCell growthCell differentiationApoptosisEpigenetic regulation
04
Disease associations
CancerEpigenetic dysregulation
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