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Target intelligence / Profile preview
Histone deacetylase 5 (HDAC5)
- Target
- HDAC5
- Molecular classification
- Enzyme, Histone deacetylase, Class IIa HDAC
01
Overview
Histone deacetylase 5 (HDAC5) is an enzyme that regulates gene expression by modifying chromatin structure. It belongs to the class IIa family of histone deacetylases and plays a role in various cellular processes including cell cycle progression, differentiation, memory consolidation, cancer cell migration/invasion, and immune modulation. Its activity is modulated by phosphorylation and it interacts with multiprotein complexes to exert its effects.
- Other names
- HD5NY-CO-9KIAA0600Antigen NY-CO-9
02
Mechanism of action
HDAC inhibition leading to altered gene expression
03
Biological functions
Regulation of gene expressionChromatin modificationTranscriptional repressionCell cycle progressionCell differentiationMemory consolidationImmune modulationEpithelial-to-mesenchymal transition (EMT)Regulation of glucose metabolism
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Selectivity challenges due to structural similarities within the HDAC family
06
Interacting drugs
JNJ-26481585
1 more in the full profile.
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