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Histone deacetylase 6 (HDAC6)
- Target
- HDAC6
- Molecular classification
- Enzyme, Histone Deacetylase, Class IIb Histone Deacetylase
01
Overview
Histone deacetylase 6 (HDAC6) is a unique member of the histone deacetylase family, classified as a class IIb HDAC. Unlike most other HDACs, which are primarily nuclear, HDAC6 is predominantly localized in the cytoplasm and acts on both histone and non-histone substrates. It plays critical roles in cellular processes such as protein degradation, cell motility, stress response, and regulation of microtubule dynamics. It is a therapeutic target for cancer, neurodegenerative diseases and cardiovascular diseases.
- Other names
- HD6
02
Mechanism of action
Inhibition of HDAC6 deacetylase activity, leading to increased acetylation of target proteins (e.g., α-tubulin, HSP90) and altered cellular processes.
03
Biological functions
Protein deacetylationRegulation of microtubule dynamicsStress responseProtein quality controlRegulation of cell motilityRegulation of protein degradationAutophagyAggresome formation
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseAlzheimer's disease
05
Safety considerations
Potential off-target effects of non-selective HDAC inhibitorsDevelopment of resistance to HDAC6 inhibitorsPotential for drug-drug interactions
06
Interacting drugs
HDAC6 inhibitors
1 more in the full profile.
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