Histone deacetylase 6 mRNA (HDAC6 mRNA)

Histone deacetylase 6 (HDAC6) mRNA is the messenger RNA transcript that encodes the HDAC6 enzyme, a unique member of the Class IIb histone deacetylase family. Unlike most other HDACs that reside in the nucleus and modify histones, the protein product of HDAC6 mRNA is primarily localized in the cytoplasm, where it regulates the acetylation status of non-histone substrates such as alpha-tubulin, Hsp90, and cortactin (UniProt, Q9UBN7). This mRNA is a critical therapeutic target because its protein product plays a pivotal role in microtubule-dependent transport, the aggresome pathway for protein degradation, and cell motility (NCBI Gene, 10013). Dysregulation of HDAC6 mRNA levels and subsequent protein overexpression are associated with various pathologies, including multiple myeloma, breast cancer, and neurodegenerative disorders like Alzheimer's and Charcot-Marie-Tooth disease (PubMed, PMID: 30214344). Therapeutic strategies targeting the mRNA, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), aim to selectively reduce HDAC6 protein levels to restore cellular homeostasis and microtubule stability (PubMed, PMID: 28811345). These RNA-targeted approaches offer a high degree of specificity compared to small molecule inhibitors, potentially minimizing off-target effects associated with the catalytic domains of other HDAC isoforms.

Other names

HDAC6 transcriptHistone deacetylase 6 messenger RNAHDAC6 gene transcript

Degradation of the mRNA transcript via RNA interference (RNAi) or RNase H-mediated cleavage, leading to reduced translation and depletion of the HDAC6 protein.