Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Histone Deacetylase 7 (HDAC7)
- Target
- HDAC7
- Molecular classification
- Enzyme, Histone modification
01
Overview
Histone deacetylase 7 (HDAC7) is a member of the class IIa histone deacetylases, functioning as both a lysine deacetylase and scaffolding protein. It plays crucial roles in signal transduction and gene regulation, impacting numerous cellular and developmental processes. In the nucleus, it generally inhibits gene expression by promoting chromatin condensation through histone deacetylation. Dysregulated expression/function of HDAC7 has been associated with autoimmune diseases and various cancers.
- Other names
- Histone deacetylase 7AProtein deacetylase HDAC7HDAC7A
02
Mechanism of action
Vorinostat: Pan-HDAC inhibition
03
Biological functions
Regulation of gene expressionHistone deacetylationSignal transductionRegulation of cell differentiationRegulation of cell deathRegulation of cell proliferationScaffolding protein
04
Disease associations
Autoimmune diseasesCancerCardiovascular diseaseOsteogenesis related defects
05
Safety considerations
Dysregulation linked to tumor progression/metastasisAberrant levels associated with drug resistancePotential for immune dysregulation
06
Interacting drugs
Vorinostat
Beyond the preview
Go deeper on Histone Deacetylase 7 (HDAC7).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Histone Deacetylase 7 (HDAC7).