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Target intelligence / Profile preview
Histone Deacetylase 8 (HDAC8)
- Target
- HDAC8
- Molecular classification
- Enzyme, Histone modification, Class I Histone Deacetylase, Carbon-nitrogen hydrolase
01
Overview
Histone deacetylase 8 (HDAC8) is a zinc-dependent enzyme that removes acetyl groups from lysine residues on histone proteins, leading to chromatin condensation and transcriptional repression. It is involved in cell cycle regulation, chromosome segregation, and developmental events. Dysregulation of HDAC8 is associated with Cornelia de Lange syndrome and various malignancies, making it a target for cancer therapy.
- Other names
- Histone deacetylase-8HDACL1HD8CDA07
02
Mechanism of action
Inhibition of histone deacetylation, leading to increased histone acetylation and altered gene expression.
03
Biological functions
Chromatin remodelingGene silencingCell cycle controlChromosome cohesion/separationEpigenetic repression
04
Disease associations
CancerCornelia de Lange syndromeAcute myeloid leukemiaT-cell lymphomasNeuroblastomaSolid tumors/cancersDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to the presence of other HDAC isoforms.Potential developmental toxicity due to role in chromosome segregation.
06
Interacting drugs
Trichostatin A
2 more in the full profile.
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