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Target intelligence / Profile preview
Histone deacetylase 9 (HDAC9)
- Target
- HDAC9
- Molecular classification
- Enzyme, Histone modification, Histone deacetylase, Class IIa histone deacetylase
01
Overview
Histone deacetylase 9 (HDAC9) is an enzyme that removes acetyl groups from lysine residues on histone and non-histone proteins, leading to altered gene expression. It plays roles in development, immunity, and disease. Dysregulation of HDAC9 is implicated in cancer and cardiovascular disease, making it a therapeutic target.
- Other names
- MITR (Myocyte enhancer-binding factor 2-interacting transcriptional repressor)
02
Mechanism of action
Inhibition of HDAC9
03
Biological functions
DeacetylationRegulation of gene expressionCardiac muscle developmentBone formationAdipocyte differentiationInnate immunityHematopoiesisCell cycle progressionApoptosis regulationDNA-damage responseAutophagy regulation
04
Disease associations
CancerCardiovascular DiseaseAtherosclerosisAuriculocondylar Syndrome 4Primary Cutaneous T-cell Non-Hodgkin Lymphoma
05
Interacting drugs
TMP195
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