Histone Deacetylase Class I (HDAC Class I)

Histone deacetylase class I enzymes are central regulators of epigenetic silencing through their enzymatic removal of acetyl groups from nuclear proteins, primarily within multi-protein repressor complexes. They are important drug targets across oncology and neurology fields due to their broad impact on gene expression programs. Class I HDACs include HDAC1, HDAC2, HDAC3, and HDAC8, which function as part of large multiprotein complexes such as NuRD, Sin3, CoREST, MiDAC, and SMRT/NCoR. Dysregulation of Class I HDACs has been linked to various diseases, including cancers and neurological disorders like schizophrenia. Inhibitors are under clinical investigation or approved for certain cancers.

Other names

HDAC1HDAC2HDAC3HDAC8

Inhibition of histone deacetylase activity, leading to increased histone acetylation and altered gene expression.