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Target intelligence / Profile preview
Histone Deacetylase Class IIb (HDAC Class IIb)
- Target
- HDAC Class IIb
- Molecular classification
- Enzyme, Histone Modification, Histone Deacetylase
01
Overview
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysine residues on histones and non-histone proteins, thereby influencing chromatin structure and gene expression. Class IIb HDACs consist of two members: HDAC6 and HDAC10. HDAC6 is the main cytoplasmic deacetylase, targeting cytoskeletal proteins and playing roles in cell motility, protein degradation, stress response, and immune signaling. HDAC10 is structurally similar and may be involved in DNA repair and autophagy. Both enzymes are zinc-dependent and have become attractive therapeutic targets for cancer and neurodegenerative diseases.
- Other names
- HDAC6/10HDAC6 and HDAC10Class IIb HDACsHDAC family IIb
02
Mechanism of action
Inhibition of histone deacetylase activity
03
Biological functions
Gene expression regulationChromatin remodelingProtein traffickingCytoskeleton dynamicsStress responseDeacetylationDNA repairAutophagy
04
Disease associations
CancerNeurodegenerative diseaseInflammation
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