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Histone Deacetylase Enzyme (HDAC)

Target: HDAC
Molecular classification: Enzyme, Histone modification

Overview

Histone deacetylases (HDACs) are a family of enzymes that catalyze the removal of acetyl groups from lysine residues on histone and non-histone proteins. This enzymatic activity leads to chromatin condensation and transcriptional repression, playing a central role in the regulation of gene expression.

Mechanism of action

HDAC inhibition

Biological functions

Regulation of gene expressionCell growthCell deathDevelopmentSignal transductionCell cycle control mechanismsNeurodevelopmental processes

Disease associations

CancerNeurodegenerative diseaseGenetic disordersDevelopmental syndromes

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