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Target intelligence / Profile preview
Histone deacetylase Hos2 (None)
- Target
- None
- Molecular classification
- Enzyme, Histone modification, Class I HDAC
01
Overview
Histone deacetylase Hos2 is a Class I histone deacetylase (HDAC) found in yeast and other fungi. It is responsible for the removal of acetyl groups from lysine residues on the N-terminal tails of core histones, including H2A, H2B, H3, and H4. This activity plays a crucial role in chromatin remodeling and gene expression regulation. It acts both as a repressor and activator of transcription. In Saccharomyces cerevisiae, Hos2 negatively regulates protein expression noise by modulating the translation machinery.
02
Mechanism of action
Inhibits histone deacetylation, altering chromatin structure and gene expression.
03
Biological functions
Regulation of transcriptionChromatin remodelingDeacetylationGene silencingGene activationModulation of protein noiseCellular stress responseCell cycle control
04
Disease associations
Infection
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