Histone H1.10 (H1-10)

Histone H1.10 is a replication-independent linker histone variant, encoded by the H1-10 (H1FX) gene, and is a member of the histone H1 family[4]. It acts as a chromatin architectural protein by binding to linker DNA between nucleosomes and promoting condensation of nucleosome arrays into higher-order chromatin structures[1][2][3][4][5]. Unlike core histones (H2A, H2B, H3, H4), H1.10 does not form part of the nucleosome "bead," but stabilizes the overall chromatin fiber, regulates DNA accessibility, and thereby modulates gene expression, nucleosome spacing, and chromatin folding[2][3][4]. H1.10 is predominantly expressed in differentiated cells and is considered critical for maintaining genome organization, epigenetic state, and cellular identity[2][4][5]. No drugs are known to specifically target Histone H1.10, and its direct use as a therapeutic target or biomarker is currently not established. Disruption of H1 variants, including H1.10, can significantly impact global chromatin condensation and gene regulation[5]. Key post-translational modifications (e.g., phosphorylation, acetylation, methylation) regulate its chromatin binding dynamics and function[2][5].

Other names

H1.10 linker histoneH1FXH1XHistone H1xhistone H1xH1 histone family member XMGC15959MGC8350