Histone H2A type 1 (H2AC11)

Histone H2A type 1 (H2AC11) is a core histone protein and a component of the nucleosome, the basic unit of chromatin structure in eukaryotic cells[2][3][5]. Two molecules of each core histone (H2A, H2B, H3, and H4) assemble into an octamer, around which DNA coils to form nucleosomes, enabling the efficient packaging and regulation of the genome[2][3][8]. H2AC11 is a replication-dependent canonical histone, meaning it is primarily synthesized and incorporated during DNA replication in S-phase. Its primary functions involve maintaining chromatin structure, controlling DNA accessibility, and contributing to fundamental processes such as transcription regulation, DNA repair, replication, and chromosomal stability[2][3][8]. While not a direct therapeutic target (such as an enzyme or receptor), altered expression of core histones, including H2A family members, has been observed in certain cancers and other disorders linked to chromatin dynamics or genome instability[2][4]. There are no direct drugs or approved biomarkers targeting this canonical histone specifically.

Other names

H2A clustered histone 11H2AFPHIST1H2AGH2AFCHIST1H2AIH2AFDHIST1H2AKH2AFIHIST1H2ALH2AFNHIST1H2AMH2A.1pH2A/fH2A/pH2A.1bHistone H2A/ptlH2AC13H2AC15H2AC16H2AC17H2AGhistone cluster 1 H2A family member ghistone 1 H2ag