Histone H2A type 1-A (H2AC1)

Histone H2A type 1-A (H2AC1) is a core component of the nucleosome, the fundamental unit of chromatin in eukaryotes, encoded by the intronless gene HIST1H2AA[1][3][7]. H2A is one of the four histone types (H2A, H2B, H3, H4) that assemble as an octamer to package approximately 146 base pairs of DNA into nucleosomes, compacts chromatin, and regulates DNA accessibility[1][3][8]. Histone H2A family members play critical roles in facilitating chromatin structure, genome stability, DNA replication, DNA repair, and transcriptional regulation[1][3][8]. Altered histone expression or variant incorporation can influence chromatin dynamics and has been implicated in various diseases, especially cancer[8]. No drugs selectively target this canonical histone protein; instead, clinical efforts focus on enzymes that modify histones globally (such as HDAC, HAT, and methyltransferase inhibitors)[4]. H2A type 1-A is not a receptor, enzyme, or direct drug target, but is fundamentally important for cell viability and gene regulation.

Other names

H2A clustered histone 1H2AAH2AFRbA317E16.2TH2Ahistone cluster 1H2aahistone cluster 1 H2A family member aHIST1H2AAHISTH2AAHistone H2A/r

Not applicable for this canonical histone; histone-modifying drugs (like HDAC inhibitors) act indirectly by altering histone post-translational modifications