Histone H2A type 1-C (H2AC6)

Histone H2A type 1-C (H2AC6) is a core component of the nucleosome, the fundamental structural unit of chromatin in eukaryotic cells[1][2]. Two molecules of each core histone (H2A, H2B, H3, H4), including H2A type 1-C, assemble into an octamer which DNA wraps around to form nucleosomes, facilitating chromatin compaction and regulating DNA accessibility for key processes such as transcription, DNA replication, and DNA repair[1][2]. H2AC6 is a replication-dependent, intronless gene expressed during S-phase, and its mRNA lacks a polyA tail but features a unique stem-loop 3’ end[1][2]. Mutations in H2AC6 have been linked to neurodevelopmental disorders with features such as developmental delay, epilepsy, and cerebellar atrophy[3]. It is not established as a therapeutic target or druggable protein, but perturbations in its function or structure can have significant consequences for chromatin architecture and genome stability[1][2][3].

Other names

H2A clustered histone 6H2A/lH2AFLHIST1H2ACdJ221C16.4Histone H2A/lhistone cluster 1 H2A family member chistone H2A histone family member Lhistone 1H2achistone H2AC