Histone H2A type 1-H (H2AC12)

Histone H2A type 1-H (H2AC12) is a member of the H2A core histone protein family, essential for the packaging of DNA into nucleosomes and formation of chromatin in eukaryotic cells[1][3]. Like other core histones, it contributes to the organization of chromatin, regulates DNA accessibility, and impacts gene expression through nucleosome assembly. The H2A family is highly diverse, containing multiple variants that influence chromatin dynamics and DNA-related processes such as repair, transcription, and cell cycle regulation[1][3]. Some H2A family members, including canonical forms like H2A type 1-H, have also been implicated in cellular antimicrobial responses and the DNA damage response. There is no evidence that H2AC12 functions as a direct therapeutic target (receptor, enzyme, transporter, etc.), and it does not currently represent a specific drug target, predictive biomarker, or clinical safety concern[1][3]. Alterations or mutations in histone genes in general can play a role in genome instability and are associated with various diseases including cancer, but not in an isoform-specific manner.

Other names

HIST1H2AHHIST1H2AIH2AFALiidJ86C11.1H2A/SH2A-clustered histone 12Histone H2A/sH2AHH2A histone family memberhistone H2A/shistone cluster 1 H2A family member hhistone cluster 1H2ah

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