Histone H2A type 1-J (H2AC14)

Histone H2A type 1-J (H2AC14) is a member of the core histone H2A family, encoded by the intronless gene HIST1H2AJ on chromosome 6p22-p21.3[4][6]. Like other H2A histones, it forms part of the histone octamer around which DNA is wrapped in nucleosomes—structures fundamental to chromatin organization in eukaryotic cells[4][5][6]. Two molecules each of H2A, H2B, H3, and H4 form the nucleosome core, enabling compaction and regulation of DNA accessibility[4][5]. H2A family members are critical for genome stability, chromatin higher-order packaging, and modulation of gene transcription by modifying nucleosome dynamics and thereby impacting DNA repair, replication, and transcriptional processes[2][4]. H2A type 1-J is a canonical, replication-dependent histone lacking a polyA tail, instead terminating with a palindromic sequence[4][6]. While core histones and their variants play fundamental roles in cellular proliferation and gene regulation, to date, H2A type 1-J itself is not considered a unique therapeutic target, nor are there clinical drugs or established diagnostics directly involving this specific protein. Alterations in core histone composition can contribute to oncogenesis and chromatin-related diseases but are typically studied in the context of broad chromatin regulatory networks rather than individual canonical H2A members[2][4].

Other names

H2AC14H2A clustered histone 14H2A/EH2AFEHIST1H2AJHistone cluster 1 H2A family member jhistone cluster 1, H2ajdJ160A22.4

Not applicable (no specific drugs targeting H2A type 1-J; role in chromatin assembly and structure)