Histone H2A type 2-A (H2AC18)

Histone H2A type 2-A (H2AC18) is a replication-dependent core histone protein and part of the histone H2A family, encoded by an intronless gene within a histone gene cluster on chromosome 1. Together with the other three core histones (H2B, H3, and H4), it forms an octameric complex around which DNA is wrapped to create nucleosomes, the fundamental units of chromatin structure in eukaryotes. This protein plays a vital role in condensing DNA into chromatin, thereby regulating DNA accessibility for transcription, replication, and repair processes. Modifications and the specific incorporation of H2A or its variants can profoundly affect nucleosome stability and chromatin architecture, impacting gene expression and genome integrity. While alterations in core histones may be associated with some diseases, H2A type 2-A itself is not considered a classic therapeutic target such as a receptor or enzyme[1][3][4].

Other names

H2A clustered histone 18H2AFOHIST2H2AAHIST2H2AA3HIST2H2AA4H2A.2H2A/qH2A-clustered histone 19Histone H2A.2Histone H2A/oH2AH2A/OH2AC19H2a-615H2A histone family, member Ohistone 2H2aa3histone cluster 2 H2A family member a3