Histone H2A type 2-B (H2AC21)

Histone H2A type 2-B (H2AC21) is a core histone protein that, along with H2B, H3, and H4, forms the histone octamer around which DNA winds to create nucleosomes, the fundamental units of chromatin structure in eukaryotic nuclei[2][4]. H2A variants, including H2AC21, display significant sequence divergence in their terminal regions, which can influence nucleosome stability, DNA accessibility, and chromatin fiber formation[2]. These properties are essential for cellular processes including DNA replication, gene expression regulation, DNA repair, and higher-order chromatin dynamics[2][4]. Post-translational modifications of H2A (such as monoubiquitylation) can participate in DNA repair-induced chromatin remodeling[4]. While some histone variants (such as H2A.X) have a more direct role in genome stability and DNA repair, H2AC21 is primarily a component of the canonical histone pool in humans and is not itself a common drug target, receptor, or disease biomarker. Not a classic drug target or receptor; rather, H2AC21 is a protein component essential for fundamental chromatin structure and function[2][4]. Roles in health and disease are mostly indirect, via its influence on the epigenome. No drugs are known to directly or selectively target H2AC21. Not used as a biomarker in clinical practice.

Other names

H2A clustered histone 21H2AC21HIST2H2ABH2ABhistone H2A type 2-Bhistone cluster 2, H2A family member b

Not applicable (no direct therapeutics or drugs established for H2AC21)