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Target intelligence / Profile preview
Histone H2B (H2B)
- Target
- H2B
- Molecular classification
- Histone, Chromatin remodeling
01
Overview
Histone H2B is one of the five main histone proteins that play a central role in the structure and function of chromatin in eukaryotic cells. It is a basic, positively charged nuclear protein essential for organizing DNA into nucleosomes, thereby facilitating chromosome packaging, transcription regulation, DNA replication, repair, and maintaining chromosomal stability. Post-translational modifications on H2B influence gene expression patterns by altering chromatin compaction or recruiting regulatory proteins. Alterations or mutations affecting histone H2B or its modifying enzymes can disrupt normal gene regulation, with implications for diseases such as cancer.
02
Mechanism of action
Modulation of chromatin structure and gene expression through post-translational modifications.
03
Biological functions
Chromosome packagingTranscription regulationDNA replicationDNA repairChromosomal stabilityEpigenetic regulation
04
Disease associations
CancerEpigenetic misregulation
05
Safety considerations
Off-target effects of epigenetic drugsPotential for global changes in gene expression
06
Biomarkers
Acetylation status of specific lysine residues (e.g., H2BK5ac)Expression levels of H2B variants
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