Histone H2B type 1-B (H2BC3)

Histone H2B type 1-B (H2BC3) is a core component of the nucleosome, the fundamental unit of chromatin in eukaryotic cells. It is a basic nuclear protein that, together with other histone proteins (H2A, H3, and H4), forms the nucleosome octamer around which DNA is wrapped, enabling condensation and organization of DNA within the nucleus. H2BC3 is involved in essential biological processes such as transcription regulation, DNA replication, DNA repair, and maintenance of chromosomal stability. Post-translational modifications of H2BC3, such as acetylation, phosphorylation, and ubiquitination, play a central role in regulating chromatin structure and gene expression. Variants and modifications of H2B are implicated in processes including the DNA damage response and regulation of active transcription, while alterations or mutations in histones have been associated with diseases such as cancer and certain genetic syndromes[1][2][5]. No approved or investigational drugs currently target H2BC3 directly, and it is generally not considered a therapeutic target due to its essential and ubiquitous structural role in all nucleated cells[1][2][5].

Other names

H2B clustered histone 3H2BC3H2BFFHIST1H2BBH2B/fHistone H2B.1Histone H2B.fH2B.1histone cluster 1 H2B family member bH2B histone family, member FH2bb