Target intelligence / Profile preview

Histone H2B type 1-D (H2BC5)

Target: H2BC5
Molecular classification: Histone, Chromatin-associated protein, Other (replication-dependent histone protein)

Overview

Histone H2B type 1-D (H2BC5) is a basic nuclear protein encoded by the intronless HIST1H2BD gene, found within the large histone gene cluster on chromosome 6p22-p21.3. It is a replication-dependent member of the histone H2B family, comprising part of the nucleosome core around which DNA is wrapped. Nucleosomes regulate accessibility of DNA to transcriptional machinery, contributing centrally to transcription regulation, DNA replication, repair, and chromosomal stability. Post-translational modifications of histones constitute a 'histone code' governing recruitment of transcription factors and chromatin-remodeling complexes. Dysregulated histone expression and modification are linked to cancer and other diseases; in particular, some evidence suggests association of H2BC5 with glioma susceptibility and hematologic cancers

Other names: H2BC5HIST1H2BDH2B Clustered Histone 5H2BFBHistone Cluster 1 H2B Family Member DHIRA-Interacting Protein 2Histone H2B Type 1-DH2B/BHistone H2B.1 BHIRIP2HIST1H2BEHIST1H2BCHIST1H2BFHIST1H2BGHIST1H2BIH2BFAH2BFGH2BFHH2BFKH2BFLdJ221C16.6histone cluster 1 H2B family member dH2B/aH2B/bH2B/gH2B/hH2B/kH2B/l

Biological functions

DNA packaging in nucleosomesTranscription regulationChromosomal stabilityDNA repairDNA replication

Disease associations

Cancer (notably glioma susceptibility and hematologic malignancies, by association with altered chromatin states)Other (epigenetic dysregulation has wide disease relevance)

Beyond the preview

Go deeper on Histone H2B type 1-D (H2BC5).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Histone H2B type 1-D (H2BC5).

Explore the full profile