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Target intelligence / Profile preview
Histone H2B type 1-J (H2BC11)
- Target
- H2BC11
- Molecular classification
- Histone, Nuclear protein, Chromatin component
01
Overview
Histone H2B type 1-J (H2BC11) is a core component of nucleosomes, the fundamental DNA-protein complex that organizes chromatin in eukaryotic cells[1][4]. Along with other core histones (H2A, H3, H4), it binds DNA and helps form the repeating nucleosome structure, enabling DNA condensation, packaging, and regulated access for processes such as transcription, replication, and repair[1][4]. The gene encoding this protein is intronless and replication-dependent, aligning with its role in packaging newly synthesized DNA[1]. Variants in H2BC11 have been identified in individuals with autism spectrum disorder, suggesting its involvement in neurodevelopment, but it is not a receptor, enzyme, or classic therapeutic target[1][4]. There are currently no drugs that selectively target H2B type 1-J for therapeutic purposes, and due to the essential nature of histones in genome function, direct inhibition is not considered a viable or safe strategy[1][4].
- Other names
- H2BC11H2B/rH2BFRHIST1H2BJH2BJHistone H2B.1Histone H2B.rhistone cluster 1 H2B family member jHistone H2B type 1-JH2B histone family, member RH2bj
02
Biological functions
Chromosome structure organizationNucleosome assemblyDNA compactionRegulation of gene expression
03
Disease associations
Neurodevelopmental disorder (autism spectrum disorder: candidate gene)Other (not a primary disease driver but variants associated with human disorders)
04
Safety considerations
Fundamental role in chromatin structure means global pharmacological inhibition is likely cytotoxic or lethal.No selective inhibitors approved or in clinical use.
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