Histone H2B type 1-L (H2BC13)

Histone H2B type 1-L (H2BC13) is a basic nuclear protein and a core component of the nucleosome, the fundamental unit of chromatin structure in eukaryotic cells[1][2][4][7]. Two molecules each of the four core histones—H2A, H2B (including H2BC13), H3, and H4—form an octamer around which approximately 146 base pairs of DNA are wrapped, enabling compaction and organization of the genome[1][2][4][6][7]. Histone H2B types, including H2BC13, are centrally involved in essential processes such as transcriptional regulation, DNA replication, and DNA repair[1][2][7]. They undergo extensive post-translational modifications (e.g., acetylation, ubiquitination, methylation, phosphorylation) that alter chromatin accessibility and influence gene expression and DNA processing[2][3]. H2BC13, like other replication-dependent histones, is encoded by an intronless gene and produced primarily during the S-phase of the cell cycle. It has a key structural role in nucleosome formation, contributing to chromosomal stability and epigenetic regulation, but is not considered a classical therapeutic target such as a receptor or enzyme[2][4][6]. Disruption of H2B genes or their modifications has been linked to cancer, including hematologic malignancies[1]. No approved drugs are known to selectively target H2BC13 directly, but global histone modifications are targets for certain epigenetic therapies.

Other names

H2B clustered histone 13H2BFCHIST1H2BLH2B/cdJ97D16.4histone H2B type 1-LH2B histone family member Chistone H2B.chistone cluster 1 H2B family member lhistone cluster 1 H2bl