Histone H2B type 1-N (H2BC15)

Histone H2B type 1-N (H2BC15) is a core component of the nucleosome, the primary structural unit of chromatin in eukaryotic cells[1][2][5][6]. Two molecules each of H2A, H2B (including H2B type 1-N), H3, and H4 form an octamer around which DNA is wrapped to form nucleosomes; these structures compact DNA, regulate DNA accessibility, and play key roles in chromatin organization, transcription regulation, DNA repair, DNA replication, and chromosomal stability[1][2][6]. This particular H2B is encoded by the intronless *HIST1H2BN* gene, located in a histone gene cluster on human chromosome 6p22-p21.3, and is expressed as a replication-dependent histone[2][1]. Post-translational modifications of H2B (such as ubiquitination) are critical for its functions in regulating chromatin dynamics and downstream histone marks[3][6]. Diseases associated with deregulation of H2B proteins include cancer and autoimmune diseases like systemic lupus erythematosus[1][2]. No approved drugs are known to specifically target H2BC15 directly[1][2][6].

Other names

H2BC15H2B clustered histone 15H2BFDHIST1H2BNH2B/dHistone H2B.dhistone H2B type 1-Nhistone cluster 1 H2B family member nH2B histone family member Dhistone 1 H2bn