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Target intelligence / Profile preview
Histone H2B type 1-O (H2BC17)
- Target
- H2BC17
- Molecular classification
- Core histone, Histone, Nuclear protein
01
Overview
Histone H2B type 1-O (encoded by the *HIST1H2BO* gene, commonly abbreviated as H2BC17) is a core nuclear protein that forms part of the nucleosome, which packages and organizes DNA into chromatin in eukaryotic cells. Two molecules each of histones H2A, H2B, H3, and H4 assemble into an octamer, around which DNA coils to form the nucleosome, the fundamental repeating unit of chromatin structure. Histone H2B type 1-O is essential for nucleosome assembly and thus participates in regulating DNA accessibility for transcription, replication, and repair, contributing to genomic integrity and chromosomal stability. H2BC17 is not considered a classical therapeutic target such as a receptor or enzyme and has no direct drug interactions or use as a clinical biomarker[1][2][6].
- Other names
- H2BC17HIST1H2BOH2B.2H2B/nH2BFNdJ193B12.2histone cluster 1 H2bohistone cluster 1 H2B family member oH2B clustered histone 17H2B histone family member N
02
Biological functions
Nucleosome assemblyChromatin organizationTranscription regulationDNA repairDNA replicationChromosomal stability
03
Disease associations
Other (no direct disease association established; histone expression and modification are broadly linked to cancer and epigenetic diseases, but there is no specific evidence for this subtype)
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