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Target intelligence / Profile preview
Histone H2B type 2-E (H2BC21)
- Target
- H2BC21
- Molecular classification
- Histone, Core histone, Chromatin structural protein, Other
01
Overview
Histone H2B type 2-E is a basic structural protein encoded by the HIST2H2BE gene in humans and is a core component of nucleosomes, which organize eukaryotic chromosomal DNA into chromatin. It forms an octameric complex together with H2A, H3, and H4 histones to wrap DNA and regulate its accessibility. This protein is involved in the regulation of transcription, DNA replication, DNA repair, and maintenance of chromosomal stability. In addition to its structural roles, Histone H2B type 2-E has been reported to exhibit antimicrobial (antibacterial and antifungal) properties. Downregulation of the HIST2H2BE gene is associated with cervical cancer progression, suggesting possible relevance as a biomarker in oncology.
- Other names
- H2B clustered histone 21H2BC21H2BFQHIST2H2BEH2B/qH2B.1H2BEH2B-GL105H2B-clustered histone 21Histone H2B-GL105Histone H2B.qGL105H2BH2BGL105H2BQhistone cluster 2 H2B family member ehistone cluster 2, H2beAV127319RGD1562346
02
Biological functions
Nucleosome assemblyChromatin compactionTranscription regulationDNA replicationDNA repairChromosomal stabilityAntimicrobial activity
03
Disease associations
CancerOther
04
Biomarkers
Possible prognostic marker for cervical preneoplastic lesion progression
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