Histone H2B.N (H2B.N)

Histone H2B.N (abbreviated H2B.N; gene: H2BN1) is a variant of the canonical histone H2B, functioning as a core component of nucleosomes in chromatin. Unlike replication-coupled canonical histones, H2B.N is predominantly expressed in mammalian oocytes and early zygotes and is thought to contribute to unusual chromatin packaging or potentially nonchromatin functions in the mammalian germline. It is part of a small group of mammalian-specific H2B variants, recently identified through phylogenomic studies. There are no known disease roles, clinical biomarkers, or targeted therapeutics associated with H2B.N at this time

Other names

H2BN1H2B.N variant histone 1histone H2B.NHistone H2A.N (note: \"Histone H2A.N\" is likely erroneous/confused with a different subclass, as H2B.N is correctly a variant of H2B)