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Histone H3 (H3)
- Target
- H3
- Molecular classification
- Histone, Chromatin protein
01
Overview
Histone H3 is a core histone protein that is essential for chromatin structure and function. It plays a critical role in DNA packaging, gene regulation, and chromosome stability. Post-translational modifications of Histone H3, such as methylation, acetylation, and phosphorylation, serve as epigenetic marks that regulate gene expression. Variants of H3 exist, including H3.1, H3.2, H3.3, CENP-A, H3.Y and H3.X which have different expression patterns across tissues, and in primates such as H3.Y, that preferentially binds in areas with open chromatin states promoting gene expression.
- Other names
- H3.1H3.2H3.3H3F3AH3F3BHIST1H3AHIST1H3BHIST1H3CHIST1H3DHIST1H3EHIST1H3FHIST1H3GHIST1H3HHIST1H3IHIST1H3JHIST2H3AHIST2H3BHIST2H3CHIST2H3DCENP-AH3.YH3.X
02
Mechanism of action
Epigenetic modulation via histone modification
03
Biological functions
DNA packagingTranscriptional regulationDNA repairDNA replicationChromosome stabilityEpigenetic regulation
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Off-target effects of epigenetic drugsPotential for dysregulation of gene expression
06
Biomarkers
H3K4me3H3K9me3H3S10 phosphorylation
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