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Target intelligence / Profile preview
Histone H3 K27M Mutant Neoepitope (H3K27M)
- Target
- H3K27M
- Molecular classification
- Neoantigen, Histone modification, Tumor-specific antigen
01
Overview
The Histone H3 K27M mutant neoepitope refers to a specific mutation in the histone H3 protein, where lysine (K) at position 27 is substituted by methionine (M). This mutation acts as a dominant negative inhibitor of PRC2, resulting in global loss of H3K27me3 and altered gene expression. It is a defining feature of diffuse midline gliomas (DMGs), including DIPG, and represents a promising target for immunotherapy due to its tumor-specific nature.
- Other names
- H3.3 K27MH3F3A K27MLysine 27 to Methionine mutation of Histone H3Histone H3 K27M
02
Mechanism of action
Induction of cytotoxic T-cell and T-helper 1 cell responses against tumor cells expressing the H3K27M neoepitope.
03
Biological functions
Eliciting immune responseTumor cell recognitionTarget for immunotherapyEpigenetic dysregulation
04
Disease associations
CancerDiffuse midline glioma (DMG)Diffuse intrinsic pontine glioma (DIPG)
05
Safety considerations
Off-target effects of immunotherapyImmune-related adverse eventsTumor escape mechanisms
06
Interacting drugs
Peptide vaccines (experimental)
1 more in the full profile.
07
Biomarkers
H3K27M mutation statusHLA allele status (for peptide binding)H3K27me3 levels
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