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Histone H3.1 (human) (H3.1)
- Target
- H3.1
- Molecular classification
- Histone, Chromatin protein, Nuclear protein
01
Overview
Histone H3.1 is a core component of nucleosomes, the basic unit of chromatin in eukaryotes, and is specifically encoded in humans by genes such as HIST1H3H (one of many histone H3 coding genes)[3][5]. It plays a central role in compacting DNA into chromatin, thereby regulating DNA accessibility for transcription, replication, DNA repair, and chromosome stability[1][3][5]. Post-translational modifications of histone H3.1—such as methylation, acetylation, and phosphorylation—create a dynamic “histone code” central to epigenetic gene regulation. While not a direct therapeutic target, aberrations in its structure or modification patterns are linked to cancer and other diseases, making its modified forms important biomarkers and biological readouts in drug development and disease monitoring[1][3][6].
- Other names
- H3C10H3 clustered histone 10HIST1H3Hhistone cluster 1 H3 family member hH3C1Histone H3/kH3F1KHIST1H3AHIST1H3BHIST1H3CHIST1H3DHIST1H3EHIST1H3FHIST1H3GHIST1H3IHIST1H3JHIST1H3KH3FAH3FLH3FCH3FBH3FDH3FIH3FHH3FKH3FFH3FJH3C11H3C12H3C2H3C3H3C4H3C6H3C7H3C8Histone H3/aHistone H3/bHistone H3/cHistone H3/dHistone H3/fHistone H3/hHistone H3/iHistone H3/jHistone H3/lH3h
02
Mechanism of action
Indirectly via agents that modulate histone post-translational modifications (e.g., methylation, acetylation)
03
Biological functions
Nucleosome assemblyChromatin organizationEpigenetic regulation of gene expressionDNA replicationDNA repairTranscription regulationMaintenance of chromosomal stability
04
Disease associations
CancerOther (in the context of disorders of chromatin structure)
05
Safety considerations
Targeting core histones directly may cause global disturbances in chromatin structure and gene expression; selective targeting of modifying enzymes is generally preferred[1].
06
Interacting drugs
None specific; however, histone-modifying enzyme inhibitors (e.g., histone methyltransferase or deacetylase inhibitors) may indirectly affect Histone H3.1 function[1][6].
07
Biomarkers
Specific post-translational modifications on histone H3 (like H3K27me3, H3K4me3) are used as epigenetic biomarkers in cancer and other diseases[1].
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